This open-access resource has been developed by Project MinE. Project MinE is an international collaboration of investigators aiming to unravel the genetic basis of Amytrofic Lateral Sclerosis (ALS). The Project MinE ALS sequencing Consortium has set out to collect whole-genome sequencing (WGS) of 15,000 ALS patients and 7,500 controls at 30X coverage. Project MinE is a largely crowd-funded initiative. As such, we are committed to sharing data and results with the scientific and healthcare communities, as well as the public more broadly. Therefor, we have create the Project MinE databrowser. We aim to share raw sequence data, provide results from our analyses, and facilitate interpretation through integration with existing datasets to serve researchers and the public across disciplines. The current dataset contains WGS data from 4,366 ALS cases and 1,832 controls. All of these 6,198 profiles have passed quality control. The data are freely available, but please see and adhere to the data access policy The pilot paper describing Project MinE has been published in the EJHG and available here The preprint describing the databrowser is available on bioRxiv
Single variants results are shown to indicate well-behaved test statistics
The depth of coverage, burden testing results and variant frequencies are based on on 4,366 Amyotrofic Lateral Sclerosis cases and 1,832 age and gender matched controls.
All data is in build hg19/GRCh37.
The allele frequencies are based on different datasets.
As a population reference we have added the gnomAD annotation of both genomes and exomes.
Please see the variant table on the gene specific pages.
Yes you can, either click here , or go to https://www.projectmine.com/research/publications/
Yes you can, please click here
Simple, just email us at firstname.lastname@example.org and indicate that you would like to check for duplicates. We will then send you an archive with checksum hashes for all the samples
Yes, if you wish to request data, please visit https://www.projectmine.com/research/data-sharing/
Please read the Project MinE Data Access Policy
If you have additional questions, please send an email to email@example.com or visit our website at www.projectmine.com
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Project MinE has made the full results from all published Project MinE studies available for download. If you download these data, you and your immediate collaborators (“investigators”) acknowledge and agree to all of the following conditions:
1) These data are provided on an "AS-IS" basis, without warranty of any type, expressed or implied, including but not limited to any warranty as to their performance, merchantability, or fitness for any particular purpose;
2) Investigators will use these results for scientific research and educational use only;
3) Downloaded Project MinE results can be shared among collaborators but the reposting or public distribution of Project MinE results files is prohibited;
4) Investigators certify that they are in compliance with all applicable local, state, and federal laws or regulations and institutional policies regarding human subjects and genetics research;
5) Investigators will cite the appropriate Project MinE publication(s) in any communications or publications arising directly or indirectly from these data;
6) For utilization of data available prior to publication, investigators will respect the requested responsibilities of resource users under 2003 Fort Lauderdale principles, which is detailed in the README file associated with the data set; and
7) Investigators will never attempt to identify any participant.
If investigators use these data, any and all consequences are entirely their responsibility.
To download data:
Please indicate your name
Please indicate a valid email address
Please indicate your institute
Agree to the terms and you will be able to download the data corresponding to each paper.